CHRONIC LOW DOSE ORAL EXPOSURE TO MICROCYSTIN-LR EXACERBATES HEPATIC INJURY IN A MURINE MODEL OF NON-ALCOHOLIC FATTY LIVER DISEASE

Chronic Low Dose Oral Exposure to Microcystin-LR Exacerbates Hepatic Injury in a Murine Model of Non-Alcoholic Fatty Liver Disease

Microcystins are potent hepatotoxins that have become a global health concern in recent years.Their actions in at-risk populations with pre-existing liver disease is unknown.We tested the hypothesis that the No Observed Adverse Cartridges Effect Level (NOAEL) of Microcystin-LR (MC-LR) established in healthy mice would cause exacerbation of hepatic

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Clr4SUV39H1 ubiquitination and non-coding RNA mediate transcriptional silencing of heterochromatin via Swi6 phase separation

Abstract Transcriptional silencing by RNAi paradoxically relies on transcription, but how the transition from transcription to silencing is achieved has remained unclear.The Cryptic Loci Regulator complex (CLRC) in Schizosaccharomyces pombe is a cullin-ring E3 ligase required for silencing that is recruited by RNAi.We found that the E2 ubiquitin co

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Plant growth promoting bacteria increases biomass, effective constituent, and modifies rhizosphere bacterial communities of Panax ginseng

Purpose: The main aim of this study was to introduce and explore plant growth-promoting bacteria (PGPB) indigenous to ginseng, and to evaluate their ability to improve production and quality, and effect on rhizosphere niche in ginseng.Materials and methods: Endophytic bacteria were isolated from root, Cartridges stem, and leaf of ginseng from diffe

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