Chronic Low Dose Oral Exposure to Microcystin-LR Exacerbates Hepatic Injury in a Murine Model of Non-Alcoholic Fatty Liver Disease
Microcystins are potent hepatotoxins that have become a global health concern in recent years.Their actions in at-risk populations with pre-existing liver disease is unknown.We tested the hypothesis that the No Observed Adverse Cartridges Effect Level (NOAEL) of Microcystin-LR (MC-LR) established in healthy mice would cause exacerbation of hepatic